Cellular Adaptation: Chapter 1 Seven Causes of Cellular Injury 1. Hypoxia 2. Infectious 3. Hypersensitivity 4. Autoimmune 5. Congenital 6. Chemical/Physical 7. Nutritional/Vitamin excess of deficiency Cellular Adaptation: 1. Dysplasia 2. Metaplasia 3. Hyperplasia 4. Hypertrophy 5. Atrophy Different Types of Necrosis 1. Liguefactive 2. Coagulative 3. Gangrenous 4. Finbrinoid 5. Fat 6. Caseous Hook It’s a broad and complex field, seeking to understand The mechanism of cellular injury and how the body can Respond and repair — cellular adaptation Of which 7 causes are identified — let’s make haste Most common is hypoxia — second is infectious Hypersensitivity — autoimmune are next — run the check list Congenital, chemical, physical forms of injury Nutritional or vitamin — excess or deficiency V1 Cause on the cellular level — the responses to injury There’s adaptation or injury reversibility. If irreversible, cell death’s the diagnosis, Either by apoptosis or necrosis LCGF2C Life Can Get Far Too Complicated So let’s see the 6 types of Necrosis: Liquefactive, Coagulative, Gangrenous, Fibrinoid, Fat, and Caseus. The craziest and most common form is Coagulative. Need an H&E Stain and microscope to examine it To see the cytoplasmic proteins denatured; Loss of nucleus with a preserved architecture. Lyrical Lectures and cellular destruction By hydrolytic enzymes — Liquefactive Necrosis — Occurs in abscesses — brain infarcts — or pancreas (ie) Leukocyte enzymes causing pus …
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